A convenient method for library construction: Parallel synthesis of β-amino ester and quinoline derivatives in liquid phase using Ln(OTf)3-catalyzed three-component reactions
✍ Scribed by Shu Kobayashi; Susumu Komiyama; Haruro Ishitani
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 163 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0006-3592
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✦ Synopsis
A convenient method for library construction in liquid phase, which is based on lanthanide triflate (Ln(OTf) 3 )-catalyzed three-component reactions, has been developed. Equimolar amounts of each component, an aldehyde, an amine, and a silyl enol ether or an alkene, react smoothly in the presence of Ln(OTf) 3 , and the work-up and purification processes are performed by simply passing through a short column. The key is to use Ln(OTf) 3 as a Lewis acid catalyst, which is not decomposed during the work-up and purification steps, and is easily separated from products by the simple procedure. According to this method, various high-quality -amino ester and quinoline derivatives have been prepared in parallel in large quantities.