A convenient method for cyanation of aromatic iodo compounds

✍ Scribed by Richard M Carr; Karl M Cable; Guy N Wells; Derek R Sutherland

• Book ID: 102370384
• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: French
• Weight: 491 KB
• Volume: 34
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580340910

✦ Synopsis

Abstract

A variety of [^13^C]‐labelled aromatic nitriles have been prepared in good yield from iodoaromatic substrates. Cyanation was achieved by reaction of aryl iodides with a mixture of potassium [^13^C]‐cyanide and copper (I) iodide in an aprotic solvent at high temperature. The use of pre‐prepared carbon‐labelled copper (I) cyanide was therefore obviated.