A convenient and efficient synthesis of heteroaromatic hydrazone derivatives via cyclization of thiosemicarbazone with ω-bromoacetophenone

✍ Scribed by Weiwei Liu; Chuanzhou Tao; Lijuan Tang; Jie Li; Yan Jin; Yueqiang Zhao; Hongwen Hu

• Book ID: 102343212
• Publisher: Journal of Heterocyclic Chemistry
• Year: 2010
• Tongue: English
• Weight: 142 KB
• Volume: 48
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.585

✦ Synopsis

Abstract

The synthesis of hydrazone derivatives containing thiazole unit was achieved with condensation of thiosemicarbazones and ω‐bromoacetophenone at room temperature. This mild, convenient, and efficient method affords the desired products with good to excellent yields. Their structures have been determined by X‐ray diffractional analysis, ^1^H‐NMR, MS, elemental analysis, and IR. Thiosemicarbazones were prepared by the condensation of thiosemicarbazide with aldehydes or ketones. J. Heterocyclic Chem., (2011).