A Convenient access to thienyl-substituted phthalazines
β Scribed by M. Manuela M. Raposo; Ana M. B. A. Sampaio; G. Kirsch
- Book ID
- 102344908
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2005
- Tongue
- English
- Weight
- 101 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0022-152X
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π SIMILAR VOLUMES
2-Nitro-5-methoxybenzaldehyde is converted to amines 2 and 7 via two alternative routes. Upon diazotisation and Sandmeyer reaction, halides 4 and 9 are formed, which, through lithiation and formylation lead to the o-phthalaldehyde. Further cyclisation with hydrazine gives the 5-methoxy-substituted p
## Abstract magnified image A highly enantioselective approach towards the synthesis of __Ξ²__βsubstituted chiral ketones by utilizing __Grignard__ reagents was achieved. The (__R__)β and (__S__)βantipodes of the target chiral ketones **2a**β**2k** were obtained with up to 100% ee from chiral __N__