A controlled study of the effects of diphenylhydantoin on anxiety, irritability, and anger in neurotic outpatients

✍ Scribed by Joseph H. Stephens; John W. Shaffer

• Publisher: Springer
• Year: 1970
• Tongue: English
• Weight: 758 KB
• Volume: 17
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00402707

✦ Synopsis

In a six-week double-blind cross-over study, DPH, 100 rag, t.i.d., was found to be markedly more effective than DPH, 5 rag, t.i.d., used as a placebo, in reducing symptoms relating to anger, irritability, impatience, and anxiety. The psychoactive properties of DPH were demonstrated by both self-ratings and physician ratings of change. Improvement when changing from 5 mg to 100 mg was matched by worsening when changing from 100 mg to 5 rag. Patients in the controlled study were selected on the basis of the presence of symptoms of anger, irritability, and anxiety, a social class more typical of private patients than clinic patients, and a Barren Ego Strength score of 40 or above. No undesirable side effects were encountered.