A controlled cortical impact model of traumatic brain injury in the rat
β Scribed by C. Edward Dixon; Guy L. Clifton; James W. Lighthall; Amy A. Yaghmai; Ronald L. Hayes
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 766 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0165-0270
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The neuroprotective effects of Riluzole, a compound with several mechanisms of action including the inhibition of sodium channel activity and glutamate release, were evaluated in a rat model of parasagittal fluid-percussion (FP) brain injury. Male Sprague-Dawley rats (350-400 g, n β«Ψβ¬ 17) were anest
## Abstract Traumatic brain injury is followed by increased extracellular glutamate concentration. Uptake of glutamate is mainly mediated by the glial glutamate transporters GLAST and GLTβ1. Extent and distribution of GLAST and GLTβ1 were studied in a rat model of controlled cortical impact injury