A controlled clinical trial of fluorouracil plus imidazole carboxamide dimethyl triazeno plus vincristine plus bis-chloroethyl nitrosourea plus radiotherapy in stomach cancer

✍ Scribed by Falkson, Geoffrey ;van Eden, Errol B. ;Sandison, A. G.

• Publisher: John Wiley and Sons
• Year: 1976
• Tongue: English
• Weight: 403 KB
• Volume: 2
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/mpo.2950020202

✦ Synopsis

Abstract

The aim of this study was to seek a better treatment for patients with inoperable or recurrent stomach cancer. Seventy patients were randomly allocated to receive courses of treatment with either A (5‐Fluorouracil plus radiotherapy) or B (5‐Fluorouracil plus Imidazole Carboxamide Dimethyl Triazeno plus Vincristine plus Bis‐Chloroethyl Nitrosourea plus radiotherapy). Only 59 of these patients were evaluable. The median survival time of patients allocated to Group A was 220 days and Group B was 199 days. Seventeen of 31 patients in Group A and 10 of 28 patients in Group B had objectively documented remission. The median survival time of responders was 222 days for Group A and 410 for Group B. While it would appear that those patients who respond to the more intensive treatment do better, a larger percentage of patients responded to the simpler treatment regimen of 5‐Fluorouracil plus radiotherapy.