A control trial of faecal occult blood screening for colorectal cancer: 2-year results

✍ Scribed by J. D. Hardcastle; N. C. Armitage; J. Chamberlain; T. W. Balfour; S. S. Amar

• Publisher: John Wiley and Sons
• Year: 1985
• Tongue: English
• Weight: 342 KB
• Volume: 72
• Category: Article
• ISSN: 0007-1323
• DOI: 10.1002/bjs.1800721337

✦ Synopsis

positive tests will have colorectal neoplasia, including 5-10 per cent with cancer". Improvements in specificity using vegetable peroxidase inhibitors, faecal porphyrin assays, or immunochemical tests for blood should be possible. None of these tests will discriminate between bleeding from neoplastic and non-neoplastic lesions. Field tests are required to establish improvement in specificity taking into account that the relative contribution to the false-positive rate of diet, bleeding non-neoplastic lesions, and 'normal' gastrointestinal blood loss is uncertain.