Cerium-mediated conjugate additions of (diethoxyphosphinoyl) difluoromethyllithium to cyclic vinyl sulfoxides proceeded smoothly; thermal suifoxide elimination afforded the products of formal vinylation, attaching the difluoromethylenephosphonato group to an alkenyl carbon atom. With acyclic vinyl s
โฆ LIBER โฆ
A conjugate addition-elimination route to alkenoyltrimethylsilanes
โ Scribed by Robert F. Cunico; Cui-ping Zhang
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 896 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
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The synthesis of 5-alkylidenecyclopent-2-enones is readily achieved in two steps via a one-pot conjugate addition-Peterson olefination sequence, using exo-2-trimethylsilyl-3a,4,7,7a-tetrahydro-4,7-methanoinden-1-one, followed by a retro-Diels-Alder reaction.