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A conformational change of the domain IV S6 segment of the voltage-gated sodium channel during inactivation

✍ Scribed by Vaibhavkumar S Gawali, René Cervenka, Péter Lukács…


Book ID
120890357
Publisher
Springer (Biomed Central Ltd.)
Year
2012
Tongue
English
Weight
66 KB
Volume
13
Category
Article
ISSN
2050-6511

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## Abstract The sodium channel gene __Scn8a__ encodes the channel Na~V~1.6, which is widely distributed in the central and peripheral nervous system. Na~V~1.6 is the major channel at the nodes of Ranvier in myelinated axons. Mutant alleles of mouse __Scn8a__ result in neurological disorders includi