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A conformation- and avidity-based proofreading mechanism for the TCR–CD3 complex

✍ Scribed by Wolfgang W.A. Schamel; Ruth M. Risueño; Susana Minguet; Angel R. Ortíz; Balbino Alarcón

Book ID
116577750
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
156 KB
Volume
27
Category
Article
ISSN
1471-4906

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📜 SIMILAR VOLUMES

Assembly of the TCR/CD3 complex: CD3ϵ/δ
Assembly of the TCR/CD3 complex: CD3ϵ/δ and CD3ϵ/γ dimers associate indistinctly with both TCRα and TCRβ chains. Evidence for a double TCR heterodimer model
✍ Ester San José; Almudena G. Sahuquillo; Rafael Bragado; Balbino Alarcón 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 188 KB

The TCR/CD3 complex is composed of six subunits which are expressed on the cell surface in a coordinate fashion after assembly in the endoplasmic reticulum (ER). The TCR/CD3 complex is assembled after a series of pairwise interactions involving the formation of dimers of CD3 epsilon with either CD3