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A conditional floxed (loxP-flanked) allele for the retinoic acid receptor gamma (RARγ) gene

✍ Scribed by Benoit Chapellier; Manuel Mark; Jean-Marie Garnier; Andrée Dierich; Pierre Chambon; Norbert B. Ghyselinck


Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
960 KB
Volume
32
Category
Article
ISSN
1526-954X

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✍ Julien Vermot; Jean-Marie Garnier; Andrée Dierich; Karen Niederreither; Richard 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 135 KB

Retinoic acid, the active vitamin A derivative, has pleiotropic functions during vertebrate development and postnatal life. Retinaldehyde dehydrogenase 2 (RALDH2) acts as the main retinoic acid-synthesizing enzyme during development. Mouse Raldh2 germline null mutants are early embryonic lethal and