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A concise synthesis of the O-glycosylated amino acid building block; using phenyl selenoglycoside as a glycosyl donor

✍ Scribed by Weir-Torn Jiaang; Meng-Yang Chang; Ping-Hui Tseng; Shui-Tein Chen

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 126 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)00367-1

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✦ Synopsis

A new glycosylation methodology for synthesizing a protected TF antigen is described. The key step is to use phenyl selenoglycoside as a glycosyl donor, thereby successfully establishing O-linked Fmoc-protected threoninyl monosaccharide in an excellent yield with high α selectivity. From protected D-galactal, a protected TF antigen building block is obtained in 40% total yield.

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