Synthetic and computational studies on l
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Yanzhong Zhang; E. Zachary Oblak; Erin S.D. Bolstad; Amy C. Anderson; Jerry P. J
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Article
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2010
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Elsevier Science
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French
⚖ 485 KB
The natural product liphagal has been shown to function as a reasonably potent and selective inhibitor of the key signaling enzyme PI-3Ka. We have been interested in developing an analog class of PI-3K inhibitors based upon this unusual terpenoid natural product. Toward that end, we have evaluated t