𝔖 Bobbio Scriptorium
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A concise synthesis of the bioactive meroterpenoid natural product (±)-liphagal, a potent PI3K inhibitor

✍ Scribed by Goverdhan Mehta; Nachiket S. Likhite; C.S. Ananda Kumar


Book ID
108285621
Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
509 KB
Volume
50
Category
Article
ISSN
0040-4039

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The natural product liphagal has been shown to function as a reasonably potent and selective inhibitor of the key signaling enzyme PI-3Ka. We have been interested in developing an analog class of PI-3K inhibitors based upon this unusual terpenoid natural product. Toward that end, we have evaluated t