A concise synthesis of piperazine-2-carboxylic acids via β-lactam-derived α-amino acid N-carboxy anhydrides
✍ Scribed by Claudio Palomo; Iñaki Ganboa; Carmen Cuevas; Carlos Boschetti; Anthony Linden
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 196 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
3S, 4R)-and (3R, 4S)-3-hydroxy-4-rerr-butyl &lactams on exposure to IM NaOCl and a catalytic amount of 2,2,6,6-tetramethy lpiperidinyl-l-oxyl (TEMPO) afforded et-amino acid N-carboxy anhydrides formally derived from both (S)-and (R)-tert-leucine amino acids. 01997 Published byElsevierScienceLtd.
A general access to 3-hydroxy-4-(1-hydroxyalkyl)-b-lactams with a C 4 -C 1 % relative configuration unlike is provided. The subsequent oxidative ring expansion of the corresponding 3-hydroxy b-lactam smoothly affords an a-amino acid N-carboxy anhydride (NCA) formally derived from (2S,3S)-b-substitut