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A concise synthesis of piperazine-2-carboxylic acids via β-lactam-derived α-amino acid N-carboxy anhydrides

✍ Scribed by Claudio Palomo; Iñaki Ganboa; Carmen Cuevas; Carlos Boschetti; Anthony Linden


Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
196 KB
Volume
38
Category
Article
ISSN
0040-4039

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A general access to 3-hydroxy-4-(1-hydroxyalkyl)-b-lactams with a C 4 -C 1 % relative configuration unlike is provided. The subsequent oxidative ring expansion of the corresponding 3-hydroxy b-lactam smoothly affords an a-amino acid N-carboxy anhydride (NCA) formally derived from (2S,3S)-b-substitut