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A concise one-pot synthesis of trifluoromethyl-containing 2,6-disubstituted 5,6,7,8-tetrahydroquinolines and 5,6,7,8-tetrahydronaphthyridines

✍ Scribed by Johnson, Russell J.; O'Mahony, Donogh J. R.; Edwards, William T.; Duncton, Matthew A. J.

Book ID: 118259516
Publisher: Royal Society of Chemistry
Year: 2013
Tongue: English
Weight: 256 KB
Volume: 11
Category: Article
ISSN: 1477-0520
DOI: 10.1039/c2ob27113c

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## Abstract __N__‐(2‐Amino‐5,6,7,8‐tetrahydro‐6‐quinazolinyl)acetamide (**9**) and __N__‐(2,4‐diamino‐5,6,7,8‐tetrahydro‐6‐quinazolinyl)acetamide (**6**) were synthesized from __N__‐(4‐oxocyclohexyl)acetamide (**5**) as novel peptidomimetic building blocks. With similar purpose, __N__‐(6‐oxo‐5,6,7,