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A concise method for the synthesis of 2-tetralone by titanium tetrachloride-promoted cyclization of 4-aryl-2-hydroxybutanal diethyl acetal

โœ Scribed by Yung-Son Hon; Rammohan Devulapally


Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
299 KB
Volume
50
Category
Article
ISSN
0040-4039

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Titanium tetrachloride-induced cyclization of 3-(0-or m-substituted p-methoxyphenyl)-2nitro acrylates (1) provided stereoselectively (4ยขt,5~)-l-oxa-2-azaspiro[4, 5]deca-2,6,9-trien-8-ones (2). Ortho-substituted p-methoxyphenyl nitroacrylates gave 2 in good yield. 3-(4'-methoxy-l'-naphthyl)-2nitroacr

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