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A Concise and Stereoselective Synthesis of threo-γ-Hydroxy-l-β-lysine Lactone

✍ Scribed by Misiti, Domenico ;Zappia, Giovanni ;Monache, Giuliano Delle

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
469 KB
Volume
1996
Category
Article
ISSN
0947-3440

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✦ Synopsis

Abstract

A stereoselective synthesis of threo‐γ‐hydroxy‐β‐l‐lysine lactone is reported. The threo‐amino alcohol functionality is introduced by iodine‐mediated cyclocarbamation of the electron poor allylamine 6. The D‐phenylalanine was used as starting material as synthetic equivalent to D‐aspartic acid.

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