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A Concise and Divergent Approach to Hydroxylated Piperidine Alkaloids and Azasugar Lactams

โœ Scribed by Guo, Lian-Dong; Liang, Pan; Zheng, Jian-Feng; Huang, Pei-Qiang


Book ID
120336945
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
573 KB
Volume
2013
Category
Article
ISSN
1434-193X

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A variant of Knight's route to D-mannolactam, exploring the stereoselectivity of directed oxidation conditions, reveals a tendency for hydroxylated N-tosyl lactams to rearrange to c-lactones. An attempted directed dihydroxylation in this series is shown to result in unexpectedly high anti-selectivit