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A COMPUTER PROGRAM USING DISPOSITION DECOMPOSITION ANALYSIS IN PHARMACODYNAMICS

✍ Scribed by HAIYUNG CHENG; YIMING GONG; WILLIAM J. JUSKO

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 793 KB
Volume: 18
Category: Article
ISSN: 0142-2782
DOI: 10.1002/(sici)1099-081x(199701)18:1<9::aid-bdd999>3.0.co;2-4

No coin nor oath required. For personal study only.

✦ Synopsis

A personal computer based program (DDAPD1) was developed for calculating or determining the apparent distribution function of a drug to a possibly heterogeneous biophase, the mean transit time of a drug at the biophase, the ratio of distribution clearance to biophase volume of distribution, the drug concentration±time function at the biophase (C b (t)), and a function which re¯ects the relationship between the pharmacodynamic response and C b (t) of the drug. This program uses an approach based on disposition decomposition analysis and the hysteresis minimization principle. The application of the program is demonstrated using published data for heptabarbital.

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