A computer analysis of factors influencing the cerebello-thalamo-cortical signals

✍ Scribed by Samuel H.H. Chan; Howard J. Wing

• Publisher: Elsevier Science
• Year: 1978
• Tongue: English
• Weight: 543 KB
• Volume: 11
• Category: Article
• ISSN: 0010-4809
• DOI: 10.1016/0010-4809(78)90005-8

✦ Synopsis

A computer program developed from a model on the cerebella-thalamo-cortical pathway has been used to analyze the effects of varying three mathematical constants, corresponding to latency CL), effective time range of influence (IT), and range of projection CR*), on this circuitry. using correlation coefficient (c.c.) between computer-generated and experimentally-recorded cortical responses to the same cerebella-thalamic signal at corresponding time units as the index. Optimal values for L, E, and R*, which together produce a peak C.C. between theoretical and experimental cortical field potentials, have been obtained, after sampling 1600 combinations of values of these factors. Optimization of these values have been suggested to represent the requirement of precision timing for the arrival of diverse cerebella-thalamic inputs, to concertly activate a set of efferent zones in the motor cortex, in the production of well-coordinated movements.