✦ LIBER ✦

A Computational Study of the Resistance of HIV-1 Aspartic Protease to the Inhibitors ABT-538 and VX-478 and Design of New Analogues

✍ Scribed by Anil C. Nair; Stanislav Miertus; Alessandro Tossi; Domenico Romeo

Book ID: 115581488
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 132 KB
Volume: 242
Category: Article
ISSN: 0006-291X
DOI: 10.1006/bbrc.1997.8008

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

ChemInform Abstract: Epoxyalcohol Route

ChemInform Abstract: Epoxyalcohol Route to Hydroxyethylene Dipeptide Isosteres: A New Synthesis of the Diaminoalcohol Core of HIV-Protease Inhibitor ABT-538 (Ritonavir).

✍ Fabio Benedetti; Stefano Norbedo 📂 Article 📅 2001 🏛 John Wiley and Sons ⚖ 31 KB

Changes in the Vif protein of HIV-1 asso

Changes in the Vif protein of HIV-1 associated with the development of resistance to inhibitors of viral protease

✍ Melanie A. Adekale; Patricia A. Cane; Malcolm A. McCrae 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 621 KB

## Abstract The protease (__PR__) and virus infectivity factor (__vif__) gene sequences of a cohort of HIV‐1 infected patients showing evidence of developing protease inhibitor (PI) resistance whilst undergoing highly active antiretroviral therapy (HAART) have been determined. The PR sequences show

A clinical study of the HIV-1 protease i

A clinical study of the HIV-1 protease inhibitor, 141W94 (VX-478) to evaluate a new soft gelatin capsule formulation and to determine the effects of food upon bioavailability: WT Symonds1, BM Sadler1, GE Chittick1, J Moss2. Glaxo Wellcome Research and Development, 1RTP, NC, USA and 2Greenford, Middlesex, UK

📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 129 KB

A Rational Approach to the Design of Sel

A Rational Approach to the Design of Selective Substrates and Potent Nontransportable Inhibitors of the Excitatory Amino Acid Transporter EAAC1 (EAAT3). New Glutamate and Aspartate Analogues as Potential Neuroprotective Agents

✍ Campiani, Giuseppe; De Angelis, Meri; Armaroli, Silvia; Fattorusso, Caterina; Ca 📂 Article 📅 2001 🏛 American Chemical Society 🌐 English ⚖ 236 KB

Optimization and Computational Evaluatio

Optimization and Computational Evaluation of a Series of Potential Active Site Inhibitors of the V82F/I84V Drug-resistant Mutant of HIV-1 Protease: an Application of the Relaxed Complex Method of Structure-based Drug Design

✍ Alexander L. Perryman; Jung-Hsin Lin; J. Andrew McCammon 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 642 KB

Computational studies of the binding mod

Computational studies of the binding mode and 3D-QSAR analyses of symmetric formimidoester disulfides: a new class of non-nucleoside HIV-1 reverse transcriptase inhibitor

✍ Elena Cichero; Sara Cesarini; Andrea Spallarossa; Luisa Mosti; Paola Fossa 📂 Article 📅 2008 🏛 Springer-Verlag 🌐 English ⚖ 513 KB