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A Computational Study of the Phosphorylation Mechanism of the Insulin Receptor Tyrosine Kinase

✍ Scribed by Zhou, Baojing; Wong, Chung F.


Book ID
120290030
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
221 KB
Volume
113
Category
Article
ISSN
1089-5639

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## Abstract Most insulin responses correlate well with insulin receptor (IR) Tyr kinase activation; however, critical exceptions to this concept have been presented. Specific IR mutants and stimulatory IR antibodies demonstrate a lack of correlation between IR kinase activity and specific insulin r