## Communicated by Garry R. Cutting We sought to determine the spectrum of mutations producing f3-thalassemia in Egypt using genomic PCR and a variety of mutation-screening procedures. T h i r t y four P-thalassemia and three Hb S/Pthalassemia patients originating from different regions of Egypt w
A comprehensive molecular characterization of beta thalassemia in a highly heterogeneous population
β Scribed by Haleh Akhavan-Niaki; Poupak Derakhshandeh-Peykar; Ali Banihashemi; Amrollah Mostafazadeh; Beheshteh Asghari; Mohammad-Reza Ahmadifard; Mandana Azizi; Ali Youssefi; Maryam Mitra Elmi
- Book ID
- 116304875
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 445 KB
- Volume
- 47
- Category
- Article
- ISSN
- 1079-9796
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The relative frequency of different beta-thalassemia mutations and their association with beta-globin haplotypes were studied in patients from the Nile delta region, Egypt, by means of the polymerase chain reaction, oligonucleotide hybridization and restriction analysis. We found that 8 mutations ac