A comprehensive and flexible approach to the automated-dissolution testing of pharmaceutical drug products incorporating direct UV–vis fiber-optic analysis, on-line fluorescence analysis, and off-line storage options
✍ Scribed by P. Rogers; P. A. Hailey; G. A. Johnson; V. A. Dight; C. Read; A. Shingler; P. Savage; T. Roche; J. Mondry
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 480 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0895-7533
No coin nor oath required. For personal study only.
✦ Synopsis
An automated system for on-line determination of the dissolution rates of drug-delivery formulations to USP Methods I and II is described. The system employs UV-vis spectroscopy utilizing either a fiber-optic probe for direct determination or the option of on-line flow through analysis with prior filtration. The system is also capable of on-line flow through analysis utilizing both UV-vis and fluorescence detection and an off-line storage option for further sample processing. The system also comprises a complete IT solution including a simple user interface, data archival to an NT server, remote client server interrogation of the database, and automatic report generation.