A composite polymer/tricalcium phosphate membrane for guided bone regeneration in maxillofacial surgery

✍ Scribed by Ignatius, Anita A. ;Ohnmacht, Michael ;Claes, Lutz E. ;Kreidler, Joachim ;Palm, Frank

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 218 KB
• Volume: 58
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/jbm.1055

✦ Synopsis

The aim of the study was the development of a resorbable membrane for guided bone regeneration (GBR) with improved biocompatibility, which should be stiff enough to avoid membrane collapse during bone healing. Combining a bioactive ceramic with a resorbable polymer may improve the biocompatibility and osteoconductivity of resorbable devices. The present article describes the preparation, the mechanical properties, and the in vitro degradation characteristic of a composite membrane made of poly(L, DL-lactide) and alpha-tricalcium phosphate in comparison to a membrane made of pure poly(L, DL-lactide). The tensile strength and the elastic modulus as well as the molecular weight of the membranes were measured after in vitro degradation in buffer at 37 degrees C up to 28 weeks. The initial tensile strength of the composite and the polymer membrane was 37.3 +/- 2.4 MPa and 27.7 +/- 2.3 MPa and the elastic modulus 3106 +/- 108 MPa and 3101 +/- 104 MPa, respectively. The mechanical properties remained constant up to 8 weeks and then decreased slowly until week 28. The molecular weight of both membranes decreased steadily from 170,000 D to 30,000 D. It was concluded that the mechanical requirements for a membrane for GBR were fulfilled by the composite membrane.