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A comparison of thein vitroantimicrobial activity of liposomes containing meropenem and gentamicin

✍ Scribed by Zuzanna Drulis-Kawa; Jerzy Gubernator; Agata Dorotkiewicz-Jach; Włodzimierz Doroszkiewicz; Arkadiusz Kozubek

Book ID: 111490321
Publisher: SP Versita
Year: 2006
Tongue: English
Weight: 457 KB
Volume: 11
Category: Article
ISSN: 1425-8153
DOI: 10.2478/s11658-006-0030-6

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✦ Synopsis

Abstract

The antimicrobial activity of eight cationic, two neutral and three anionic liposome compositions containing meropenem and gentamicin was tested in vitro in broth and serum medium. The cationic formulations showed better antibacterial efficacy against both Gram-positive and Gram-negative bacteria than the anionic and neutral ones, regardless of the encapsulated drug. The most effective formulations were the cationic PC/DOPE/DOTAP 3:4:3 and PC/Chol/DOTAP 3:4:3, as the MICs with meropenem were 2 to 4 times lower than those of the free drug.

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