A Comparison of the Stability of Cyanocobalamin and Its Analogs in Ascorbate Solution**Merck Sharp & Dohme Research Laboratories, Rahway, N. J.
✍ Scribed by Hutchins, Hastings H. ;Cravioto, Patricia J. ;Macek, Thomas J.
- Publisher
- Elsevier
- Year
- 1956
- Weight
- 257 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0095-9553
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✦ Synopsis
temperature in the presence of pyridine alone. I n the presence of both pyridine and thiamine, however, destruction of the vitamin was complete after six months a t room temperature and only 1 week at 45'. A t 100' for four hours destruction was complete in the presence of the mixture, whereas, only 23.2% of vitamin BIZ was lost with pyridine alone. It appears, therefore, that niacinamide or the pyridine nucleus, acts upon thiamine to form a compound that is incompatible with vitamin BIZ.
Vitamin BIZ has been found stable in low potency elixirs (2). Our studies on all oral products (not containing ascorbic acid) and elixir type products always have shown good vitamin BIZ stability. No difficulty should be encountered with these products, since the thiamine and niacinamide content is relatively low. SUMMARY 1. Studies of certain commercially available B-complex injectable products show instability of vitamin BI2 after storage a t room temperature for nine months.