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A comparison of the pharmacokinetics of codeine and its metabolites in healthy Chinese and Caucasian extensive hydroxylators of debrisoquine.

โœ Scribed by QY Yue; JO Svensson; F. Sjoqvist; J. Sawe

Book ID
117945272
Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
966 KB
Volume
31
Category
Article
ISSN
0306-5251

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โœ I. Johansson; Q. Y. Yue; M.-L. Dahl; M. Heim; J. Sรคwe; L. Bertilsson; U. A. Meye ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Springer ๐ŸŒ English โš– 402 KB

The Far Eastern and Caucasian populations are strikingly different with respect to the debrisoquine/sparteine hydroxylation polymorphism. The number of poor metabolizers, as defined for Caucasians, is very low among Chinese and Japanese. We investigated the molecular basis for this difference by ana