𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A comparison of the effect of inducers on the expression of glutathione-S-transferases in the liver of the intact rat and in hepatocytes in primary culture

✍ Scribed by S Langouet; F Morel; D J Meyer; O Fardel; L Corcos; B Ketterer; A Guillouzo


Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
702 KB
Volume
23
Category
Article
ISSN
0270-9139

No coin nor oath required. For personal study only.

✦ Synopsis


the prevention of AFB 1 -associated liver cancer in huphy.

mans, provided they are nontoxic and increase levels From 1 INSERM U49, Unite ´de Recherches He ´patologiques, Ho ˆpital Pontof those GSTs that are effective enzymes for the carcichaillou, Rennes, France; and 2 Cancer Research Campaign, Molecular Toxicolnogenic electrophile AFB 1 -exo-oxide.


📜 SIMILAR VOLUMES


Expression of cytochrome p-450s and glut
✍ Sang Geon Kim; Eun Jung Kim; Yoon Gyoon Kim; Myung Gull Lee 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 237 KB 👁 1 views

## Abstract Pharmacokinetic profiles of therapeutic agents change in dehydrated animals. The present study was designed to determine the expression of xenobiotic‐metabolizing enzymes in the rat liver and the effect of glucose supplementation during water deprivation. Deprivation of water intake, w

The effect of dehydroepiandrosterone on
✍ Xue Tang; Haitian Ma; Guoqing Huang; Jinfeng Miao; Sixiang Zou 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 434 KB 👁 1 views

## Abstract The effects of dehydroepiandrosterone (DHEA) on lipogenic gene mRNA expression were examined using cultured primary chicken hepatocytes. Cell samples were equilibrated to culture conditions for 24 h and then exposed to DHEA (1, 10 and 100 µM) dissolved in DMSO. The expression of sterol

N-nitrosodimethylamine changes the expre
✍ S. A. Sheweita; N. Mousa; H. M. Al-Masry 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 116 KB 👁 1 views

## Abstract The present study investigated the protective effect of gossypol, selenium, zinc, or glutathione (GSH) against dimethylnitrosamine (DMN)‐induced hepatotoxicity in the livers of male mice. The expression and the activity of glutathione __S__‐transferase (GST), levels of GSH, and free rad

Alteration of expression of liver-enrich
✍ Toru Mizuguchi; Toshihiro Mitaka; Koichi Hirata; Hiroaki Oda; Yohichi Mochizuki 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 555 KB

In the present study, we showed the role of the liver-enriched transcription factors in the transition during which proliferating hepatocytes become quiescent. We used primary rat hepatocytes cultured in modified L-15 medium. The cells proliferated and, after the addition of 2% dimethyl sulfoxide (D

Studies on the mechanism of haloacetonit
✍ Ahmed, Ahmed E. ;Hussein, Gamal I. ;Loh, Jiann-Ping ;Abdel-Rahman, Sherif Z. 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 672 KB

## Abstract The haloacetonitrile, dibromoacetonitrile (DBAN), is a direct‐acting genotoxic agent that has been detected in drinking water. In a time course study, male Sprague‐Dawley rats were treated with DBAN (75 mg/kg PO), and killed at 0.5, 1, 2, and 4 hr after treatment. In a dose response stu

Effects of hepatocyte growth factor on t
✍ María José Gómez-Lechón; José Castelli; Isabel Guillén; Enrique o'Connor; Toshik 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 836 KB

The effect of recombinant human hepatocyte growth factor (h-rHGF), a potent mitogen for hepatocytes, was investigated in primary cultures of human hepatocytes. Here, we describe a series of experiments to investigate the kinetics of its mitogenic action, as well as its metabolic effects on cultured