A comparison of regularly dosed oral morphine and on-demand intramuscular morphine in the treatment of postsurgical pain
β Scribed by James P. McCormack; C. Brian Warriner; Marc Levine; Ned Glick
- Book ID
- 105685531
- Publisher
- Springer-Verlag
- Year
- 1993
- Tongue
- French
- Weight
- 611 KB
- Volume
- 40
- Category
- Article
- ISSN
- 1496-8975
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π SIMILAR VOLUMES
## BACKGROUND. When a change of opioid is considered, equianalgesic dose tables are used. These tables generally propose a dose ratio of 5:l between morphine and hydromorphone. In the case of a change from subcutaneous hydromorphone to methadone, dose ratios ranging from 1:6 to 1:10 are proposed.
The single-dose and steady state kinetics of morphine given as controlled-release tablets (30 mg every 12 h) and as a solution (15 mg every 6 h) have been compared in 11 cancer patients with chronic pain. The concentrations of morphine, morphine-3-glucuronide (M3G), and morphine-6-glucuronide (M6G)