A comparison of Ktrans measurements obtained with conventional and first pass pharmacokinetic models in human gliomas
✍ Scribed by Hamied A. Haroon; David L. Buckley; Tufail A. Patankar; Graham R. Dow; Scott A. Rutherford; Danielle Balériaux; Alan Jackson
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 409 KB
- Volume
- 19
- Category
- Article
- ISSN
- 1053-1807
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✦ Synopsis
Abstract
Purpose
To compare in a group of patients with cerebral gliomas the estimates of K^trans^ between a conventionally established pharmacokinetic model and a recently developed first pass method.
Materials and Methods
Glioma patients (23) were studied using T~1~‐weighted dynamic contrast‐enhanced magnetic resonance imaging (MRI), and two alternative pharmacokinetic models were used for analysis to derive the volume transfer constant K^trans^. These were a modified version of the established model (yielding K~TK~) and a recently published method based on first pass leakage profile (FP) of contrast bolus (yielding K~fp~).
Results
We found a strong correlation between intra‐tumoral median K~TK~ and K~fp~ (rho = 0.650, P < 0.01), but the values from the conventional model were consistently and significantly higher (mean of inter‐tumoral K~fp~ and K~TK~ medians were 0.018 minute^−1^ and 0.284 minute^−1^, respectively, P < 0.001). The spatial distribution of K~TK~ and K~fp~ showed poor correlation in the presence of large vascular structures and good correlation elsewhere.
Conclusion
K~TK~ and K~fp~ produce similar biologic information within voxels not dominated by vascular tissue. The FP method avoids erroneous overestimation of K^trans^ in areas of significant intravascular contrast. Findings are in keeping with the predictions of previous mathematical simulations. J. Magn. Reson. Imaging 2004;19:527–536. © 2004 Wiley‐Liss, Inc.