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A comparison of induced mutation at homologous alleles of the tk locus in human cells

✍ Scribed by Sally A. Amundson; Howard L. Liber


Book ID
113193909
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
982 KB
Volume
247
Category
Article
ISSN
0027-5107

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One of the mammalian cell gene-mutation assays that has been used extensively for mutagenicity studies is the L5178Y/TK+'--3.7.2C mouse lymphoma assay Oberly et al., 19841. This assay measures forward mutation at the functionally heterozygous thymidine kinase (rk) locus based on resistance to trifl