A comparison of frozen and reconstituted cattle and human skin as barriers to drug penetration

✍ Scribed by Ian H. Pitman; Susan J. Rostas

• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 540 KB
• Volume: 71
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600710413

✦ Synopsis

An in uitro study of the permeabilities of frozen and reconstituted cattle skin and human skin to levamisole was done. Cattle skin was 400 times more permeable to levamisole from an organic solvent (largely 2-ethoxyethanol) than was human skin. The diffusion coefficient value of levamisole in cattle skin and the partition coefficient value of levamisole from the organic solvent into the skin suggested that a relatively large amount of drug passed through skin appendages such as hair follicles or sweathebaceous ducts. Transcellular transport across the stratum corneum was rate-determining in human skin penetration.

Keyphrases 0 Permeability-frozen and reconstituted cattle and human skin in uitro, levamisole Levamisole-in uitro permeability through frozen and reconstituted cattle and human skin 0 Dosage forms, topical-levamisole, in uitro permeability through frozen and reconsti-