A comparison of different staging systems predictability of patient outcome : Thyroid carcinoma as an example
✍ Scribed by James D. Brierley; Tony Panzarella; Richard W. Tsang; Mary K. Gospodarowicz; Brian O'Sullivan
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 166 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
✦ Synopsis
tabulating the numbers of patients within each stage group; 2) collapsing stage stitute/Princess Margaret Hospital, Toronto, Ongroupings into high and low risk groups and calculating mortality rates at 10 and tario, Canada.
15 years; 3) summing observed deviations at 5, 10, and 15 years; and 4) calculating the proportion of variance explained (PVE) for each staging classification, using each classification separately as a prognostic factor in a Cox regression model.
RESULTS.
The application of the PVE model, the only method of the four that used statistical inference, showed no statistically significant superiority of any system over the TNM classification of the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (UICC) in their ability to discriminate stage groupings.
CONCLUSIONS.
Because the TNM classification of the AJCC and UICC is universally available and widely accepted for other disease sites, the authors recommend it for all reports of the treatment and outcome of patients with thyroid carcinoma. Individual research groups also may use an alternative, validated classification to report results, provided that the outcomes are also reported using the TNM classification to facilitate comparison between different centers.