A comparison of cultured rat FRTL-5 and porcine thyroid cells for predicting the thyroid toxicity of xenobiotics
β Scribed by Atterwill, C.K.; Fowler, K.F.
- Book ID
- 122863541
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 540 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0887-2333
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The aim of the present study was to investigate the mechanisms regulating endothelin-1 (ET-1) secretion in rat thyroid FRTL-5 cells. ET-1 was found to be secreted after stimulation with adenosine and ATP. The release of ET-1 was sensitive to pertussis toxin, indicating a role of G-proteins in the st
The aim of the present study was to investigate the relationship between agonist-induced changes in intracellular free CaL+ ([Ca"],) and the refilling of intracellular CaLc stores in Fura 2-loaded thyroid FRTL-5 cells. Stimulating the cells with ATP induced a dose-dependent increase in ([Gal-' 1,).