A comparison of biphenyl 4-hydroxylation and 4-methoxybiphenyl O-demethylation in rat liver microsomes
β Scribed by Jeffrey R. Fry
- Book ID
- 115775633
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- English
- Weight
- 555 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0006-2952
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The metabolism of cyclophosphamide-44, (2-[bis(2-chloroethyI)amino]-tetrahydro-4,4-dideuterio-2H-1,3,2-oxazaphosphorine 2-oxide), was studied. The first detectable metabolite was a hydroxy derivative which was trapped with ethanol. Mass spectrometry of the resulting two ethowy derivatives and of the
Both indinavir and troleandomycin (CYP3A inhibitors) are incapable of completely inhibiting dextromethorphan metabolism to 3-methoxymorphinan in human liver microsomes. It is hypothesized that CYPs in addition to CYP3A4 and 3A5 contribute to this biotransformation. The effect of CYP-selective inhibi