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A comparison of acetaminophen and rimantadine in the treatment of influenza A infection in children

✍ Scribed by Juliette Thompson; William Fleet; Eileen Lawrence; Elizabeth Pierce; Laurie Morris; Peter Wright

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 371 KB
Volume: 21
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890210308

No coin nor oath required. For personal study only.

✦ Synopsis

Rimantadine was compared with acetaminophen in a double-blind randomly assigned therapeutic trial in 63 children presenting with influenza1 symptoms. Fortynine of the children were proven to have influenza A by culture on presentation.

Forty-three of the cultures, 88%, were influenza A/HlNl strains. Both drugs were well tolerated. Rimantadine lowered the amount of virus shed in the first 2 days after initiation of therapy. Clinical resolution of illness was not different between the two therapeutic modalities. In individuals who shed virus for 4 days, strains recovered on the last day were relatively resistant to rimantadine.

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