A comparative study on the in vitro metabolism of cisapride using subcellular liver fractions of dog, rabbit, and male and female rats

In vitro metabolism of 10-(3-chloropheny

In vitro metabolism of 10-(3-chlorophenyl)-6,8,9,10-tetrahydrobenzo[b][1,8]naphthyridin-5(7H)-one, a topical antipsoriatic agent. Use of precision-cut rat, dog, monkey and human liver slices, and chemical synthesis of metabolites

✍ Shmuel Zbaida; Yancy Du; Daniel Shannon; Donald Laudicina; C. Mohan Thonoor; Kwo 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 405 KB 👁 1 views

The metabolism of SCH 40120, which is the clinically effective antipsoriatic drug 10- (3chlorophenyl)-6,8,9,10-tetrahydrobenzol[b][1,8]naphthyridin-5(7H)-one, was determined in vitro. Rat, dog, cynomolgus monkey, and human liver slices hydroxylated the aliphatic, cyclohexenyl ring of the drug and co