A comparative study of the preparation of radioactive 4-bromoantipyrine and 4-iodoantipyrine for the measurement of cerebral blood flow

✍ Scribed by Chyng-Yann Shiue; Alfred P. Wolf

• Book ID: 102370788
• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: French
• Weight: 359 KB
• Volume: 20
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580201208

✦ Synopsis

SIJmARY

4-[82Br]Bromoantipyrine has been synthesized by three methods: the melt method, the isotopic exchange in acidic medium method and the silica gel catalyzed method. The melt method is the s i m lest one and gives the highest radiochemical yield (--90%). 4-[1311]-Iodoantipyrine has also been synthesized by these three methods with higher radiochemical yield than the bromo analog. The radiochemical yield of 4 - [ 1311] iodoantipyrine synthesized by the silica gel catalyzed method depends on the reactton time of antipyrine with [1311]NaI solution, but does not depend largely on the contact time between a n t i ~y r i n e -[ ~~~I JNal solution with silica gel. 12 or 1 ' was proposed as an intermediate for this reaction.

4-[82Br]bromoantipyrine is 9.78.