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A comparative study of the pharmacological activity of antidepressants-reversible inhibitors of monoamine oxidase A

✍ Scribed by N. I. Andreeva

Book ID
112713568
Publisher
Springer
Year
1996
Tongue
English
Weight
150 KB
Volume
30
Category
Article
ISSN
0091-150X

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## 2614W94 [3-(1-trifluoromethyl) ethoxyphenoxathiin 10,10-dioxide] is a selective, reversible inhibitor of monoamine oxidase-A with a competitive mechanism of inhibition and a K i value of 1.6 nM with serotonin as substrate. In pretreated rats, the ED 50 value after single oral dosing was 1.7 mg/