A comparative study of the effect of ryanodine on muscle

✍ Scribed by Haslett, Wilford L. ;Jenden, Donald J.

• Publisher: Wiley (John Wiley & Sons)
• Year: 1961
• Tongue: English
• Weight: 788 KB
• Volume: 57
• Category: Article
• ISSN: 0095-9898
• DOI: 10.1002/jcp.1030570210

✦ Synopsis

Previous investigations of the pharmacology of ryanodine have demonstrated that crab (Edwards, '47) and insect muscle (Edwards, '48) are sensitive to this agent, in addition to that of all vertebrates studied (e.g., Procita, '56 and Blum et al., '57). The report of mitotic inhibition by ryanodine (Cornman, '51 ) suggested that the drug might have a more general influence on contractile systems. However, motility was shown to be unaffected in Proteus morgani and Trichomonas vaginalis, and early experiments in this laboratory indicated that some invertebrates were also unaffected. In view of the negativc nature of much of the evidence pertaining to the mechanism of action of ryanodine (Blum, '57), a comparative survey of sensitivity to this drug was undertaken, with the object of correlating it with known biochemical and morphological characteristics of each muscle and species, and providing thereby a basis for a more direct approach. A preliminary account of some of this work has been published (Haslett and Jenden, '59 and Jenden and Haslett, '60).