✦ LIBER ✦
A comparative study of radioiodination of simple aromatic compounds via N-halosuccinimides and chloramine-t in TFAA
✍ Scribed by He Youfeng; H. H. Coenen; G. Petzold; G. Stöcklin
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- French
- Weight
- 413 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
A comparative study of radioiodination of simple aromatic compounds using N‐chlorosuccinimide (NCS), N‐bromosuccinimide (NBS), N‐chlorotetrafluoro‐succinimide (NCTFS) and Chloramine‐T (CAT) has been carried out in trifluoroacetic anhydride (TFAA) as an aprotic solvent. Optimization of the iodination procedure has been performed using anisole as the model substrate. A fast and simple “one‐pot” synthesis via NCTFS, NCS or CAT leads to iodoanisoles with a radiochemical yield of about 70 %. For comparison, toluene and benzene have also been radioiodinated.