A number of urban and regional plans have been developed with the advancement of urbanization and regional integration, among which the delineation of sphere of urban influence and improvement of integration between the city and its hinterland have become vital important for guiding practices. In terms of delineating sphere of urban influence, existing studies have been focused on static study by using single year data or single method, resulting in a lack of time-series longitudinal analysis or comprehensive analysis based on multiple methods. This study emphasizes on comparing two methods from both the theoretical and empirical perspective. Both gravity model and improved field model are applied to the selected study area for measurements and comparison, to explore their strengths and weaknesses. A research framework for comprehensive analysis on delineating sphere of urban influence is proposed. In the end, the differences of delineating methods are illustrated and the feasibility of comprehensive analysis is discussed. Recommendations are provided for selecting appropriate methods for delineating sphere of urban influence or developing regional hierarchy system plans and urban spatial structure schemes.