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A Comparative Study of Apoptosis and Necrosis in HepG2 Cells: Oxidant-Induced Caspase Inactivation Leads to Necrosis

✍ Scribed by Afshin Samali; Helena Nordgren; Boris Zhivotovsky; Elizabeth Peterson; Sten Orrenius


Book ID
115581591
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
103 KB
Volume
255
Category
Article
ISSN
0006-291X

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## Abstract Hepatocellular carcinoma (HCC) is resistant to chemotherapy. Recently, however, several oxaliplatin‐based combinatorial treatments have shown a promising anti‐tumor activity in patients with HCC. Presently, we demonstrate that oxaliplatin triggers necrosis more than apoptosis in HepG2,