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A comparative pharmacokinetic and pharmacodynamic study of conventional and sustained-release preparations of acebutolol in healthy volunteers

✍ Scribed by O. Fleurot; B. Lecocq; V. Lecocq; A. Le Liboux; G. Montay; A. Frydman; P. Jaillon

Book ID
115273893
Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
471 KB
Volume
5
Category
Article
ISSN
0767-3981

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We have studied a controlled-release formulation containing metoprolol 100 mg and hydrochlorothiazide 12.5 mg. We compared the pharmacokinetics of both substances and the pharmacodynamics of metoprolol with those of a conventional combination tablet. The controlled-release formulation gave less vari