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A comparative kinetics study of monochloramine and hypochlorous acid in rat

✍ Scribed by M. S. Abdel-Rahman; D. M. Waldron; R. J. Bull

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
470 KB
Volume
3
Category
Article
ISSN
0260-437X

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✦ Synopsis

The problem of trihalomethane formation now exists with the use of chlorine (technically, a mixture of HOCl and OC1-, depending on pH) as a disinfectant in drinking water. Monochloramine (NHzC1) may be considered as an alternative to HOCl as a disinfectant in public water supplies. This study was conducted to compare the kinetics of N H 2 k 1 with HO3%l in rats. The peak plasma levels of 36Cl occurred at 8 and 2 h for NH:' CI and HO3%l, respectively. The distribution of N H 2 k 1 and HO3%l was highest in plasma, while the lowest activity was observed in the fat. The half-life for 36Cl absorption was 2.49 and 2.16 h, while the elimination from plasma was 38.8 and 44.1 h after oral N H 2 k 1 and H 0 3 k l treatment, respectively. Urinary excretion accounted for most of the 36Cl eliminated in both treatments.

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