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A comparative conformational study of thymidylyl(3′ → 5′)-thymidine, thymidylyl(3′ → 5′)-5′-thio-5′-deoxythymidine and thymidinylacetomido-[3′(O) →′ (C)]-5′-deoxythymidine

✍ Scribed by C. Glemarec; Á. Nyilas; C. Sund; J. Chattopadhyaya


Book ID
118007789
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
851 KB
Volume
21
Category
Article
ISSN
0165-022X

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2D NMR spectroscopy and J coupling constant analysis are applied to resolve the structure of two photoproducts of thymidylyl-(3'----5')-thymidine. These products are cyclobutane type thymine dimers possessing the cis-syn (the predominant one) and trans-syn geometry. The cis-syn is formed in an ANTI-