✦ LIBER ✦

A comparative computer simulation study of three different sparse-sampling methods for the estimation of steady-state area under the concentration—time curve (AUC) and maximum concentration (Cmax) in toxicokinetics

✍ Scribed by Iftekhar Mahmood

Book ID: 109388738
Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 109 KB
Volume: 86
Category: Article
ISSN: 0022-3549
DOI: 10.1021/js960450i

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✍ IFTEKHAR MAHMOOD; J. TODD SAHLROOT 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 553 KB

A limited sampling model has been developed for ¯unarizine following a 30 mg oral dose in epileptic patients who were receiving phenytoin or carbamazepine or both, to estimate the area under the curve (AUC) and maximum plasma concentration (C max ). The model was developed using training data sets f