A comparative assessment of amlodipine and felodipine ER: pharmacokinetic and pharmacodynamic indices

✍ Scribed by A. D. Bainbridge; O. Herlihy; P. A. Meredith; H. L. Elliott

• Book ID: 104719284
• Publisher: Springer
• Year: 1993
• Tongue: English
• Weight: 504 KB
• Volume: 45
• Category: Article
• ISSN: 0031-6970
• DOI: 10.1007/bf00315513

✦ Synopsis

This study investigated potential therapeutic differences between Amlodipine 5 mg and Felodipine ER 10 mg in 12 normotensive/borderline hypertensive subjects by comparison of the plasma drug concentration-time profiles and the blood pressure and heart rate responses. There was significantly less trough-to-peak variability in plasma drug concentrations with amlodipine with a ratio of 67%, compared to 37% for felodipine. Correspondingly there was less variability with amlodipine in the blood pressure reductions across the dosage interval. Overall, amlodipine displayed a more consistent hypotensive effect across 24 hours and lower blood pressure values at trough, i.e. 24 hours post-dose.